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2024 University Recruiting - Computational or Structural Chemistry Intern

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Merck

Sep 27, 2023

Applications are closed

  • Internship
    Full-time
    Off-cycle Internship
  • Science
  • Boston

Requirements

  • Education:
  • Candidates must be currently enrolled in a Bachelor's degree program or higher education in chemistry, biochemistry, biophysics, informatics, computer science, applied mathematics (for Modeling & Informatics positions) or related field
  • Candidates must have completed at least two (2) years of studies towards a Bachelor's degree OR at least one (1) year towards a Master’s/Ph.D. by June 2024
  • Candidates must be continuing their education after internship completes
  • Candidate must have interest/experience in research areas relevant to the drug discovery process
  • Required Experience and Skills:
  • Candidates must be able to commit to full-time onsite employment for 10 - 12 weeks beginning June 2024
  • Candidates must have basic laboratory skills and research experience such as: protein biochemistry, biophysics, molecular biology, protein expression and purification, protein characterization using biochemical and biophysical techniques, and safe lab practices (for Protein & Structural Chemistry positions)
  • Preferred Experience and Skills:
  • Candidates should have significant interest in applying modeling/informatics methods towards drug discovery research (M&I)
  • Candidates should have Programming skills (M&I)
  • Candidates should have significant interest in protein structure/function (PSC)
  • Candidates should have experience with preparation of challenging biological macromolecules such as membrane proteins and biologics (PSC)
  • Candidates should have GPA of 3.0 or higher

Responsibilities

  • The departments of Modeling & Informatics (M&I) and Protein & Structural Chemistry (PSC) which consists of a Protein Chemistry group and Structural Chemistry groups are offering internships in the following disciplines:
  • Modeling & Informatics (M&I) - (Boston, MA; Rahway, NJ; West Point, PA; South San Francisco, CA)
  • The candidate will participate in molecular modeling and cheminformatics research, either in an independent project or as part of a drug discovery team. Prior experience with molecular modeling approaches such as docking, molecular dynamics, protein design, quantum chemical calculations, and machine learning will be beneficial. The candidate will learn how to employ data, models, and methods to drive hypothesis-driven drug discovery and will be exposed to many areas of research relevant to the drug discovery and development process.
  • Protein & Structural Chemistry: (PSC) - (Boston, MA; Rahway, NJ; West Point, PA; South San Francisco, CA)
  • The Structural Chemistry groups use X-ray crystallography and Cryo-electron microscopy to determine structures of drug/target complexes, biologics, and other relevant biological macromolecules to enable structure-based drug discovery. The successful candidate will work to support drug discovery with structural information using some or all of the following methods: protein production in prokaryotic and/or eukaryotic expression systems, preparative protein purification, labeling, characterization using SDS-PAGE, spectroscopic and analytical chromatographic methods, biochemical and biophysical pre-crystallization assays, and crystallization screening and/or sample preparation for Cryo-EM, and structure determination/analysis.
  • Protein & Structural Chemistry: (PSC) - (West Point, PA only)
  • The Protein Chemistry group enables crystallography and cryo-EM structural studies by providing high quality, well characterized recombinant proteins throughout our Company. The PSC department also develops methods for directed evolution of recombinant proteins with increased stability as well methods for membrane protein stabilization. The successful candidate will be involved in cloning, expression, purification, and biophysical characterization of recombinant proteins to support various drug discovery activities. Some molecular biology or protein chemistry lab experience is required for this position.
  • Interns will be responsible for accurate electronic notebook recording, safe laboratory practices, and presentation of data and their interpretation to a team of scientists. The intern will also attend departmental and team meetings to gain a wider perspective of the drug development process in the pharmaceutical industry.
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Merck

Science & Healthcare
Industry
10,001+
Employees

Mission & Purpose

At Merck, known as MSD outside of the United States and Canada, we are unified around our purpose: We use the power of leading-edge science to save and improve lives around the world. For more than 130 years, we have brought hope to humanity through the development of important medicines and vaccines. We aspire to be the premier research-intensive biopharmaceutical company in the world – and today, we are at the forefront of research to deliver innovative health solutions that advance the prevention and treatment of diseases in people and animals. We foster a diverse and inclusive global workforce and operate responsibly every day to enable a safe, sustainable and healthy future for all people and communities. For more information,