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Cell Therapy Clinical Pharmacology and Modeling Internship - Summer 2024

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Takeda

Dec 2, 2023

Applications are closed

  • Internship
    Full-time
    Summer Internship
  • Healthcare
    Science
  • Boston

Requirements

  • Exceptional interpersonal, verbal communication and writing skills.
  • Deadline-driven with an elevated level of organizational and planning skills.
  • Strong quantitative, analytical, problem solving and conceptual skills.
  • Proven record of accomplishment of teamwork, adaptability, innovation, initiative, and integrity.
  • Global mindset to grow in a diverse work environment.
  • Subject matter knowledge and hands-on expertise in PBPK Modeling, quantitative systems pharmacology (QSP), mechanistic PK-PD modeling, Population PK, Exposure-response
  • Experience in software packages such as Monolix, NONMEM, Symbiology, R
  • Currently authorized to work in the US (United States) without sponsorship. Takeda does not provide sponsorship for internship positions.
  • Available to work full-time (40 hours/week), within the core business hours of 8:00am – 5:00pm, for 12 weeks during the summer months.
  • Graduate, PhD, MD student with completion of a minimum of one year of university studies.
  • Must be enrolled in school the semester following your internship with Takeda.

Responsibilities

  • Due to limited clinical experience and poor understanding of clinical dose-exposure-response relationship, there is strong interest in understanding factors impacting cellular kinetics and tissue distribution of different subsets of T-cells.
  • The incumbent summer intern will work within cell therapy clinical pharmacology group and will also work with colleagues in Cell Therapy Innovation organization. The platform biodistribution studies for allogeneic T-cells across different in-house assets will be utilized and integrated within a PBCK framework. The summer intern will be responsible for developing state of the art PBPK models using mathematical modeling softwares. Differential biodistribution patterns of allogeneic T-cell subsets will be explored using sensitivity analysis. Preclinical to clinical translation of the PBCK model will be explored to potentially inform clinical dosing.
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Takeda

Better Health, Brighter Future

Science & Healthcare
Industry
10,001+
Employees

Mission & Purpose

We strive to transform lives. While the science we advance is constantly evolving, our core purpose is enduring. For more than two centuries, our values have guided us to do what’s right for patients and for society. We know that changing lives requires us to do things differently. We start by listening to and addressing what really matters to patients, the people who love them, and those in the healthcare system who provide care. And that’s what inspires us all to be bold, push boundaries and set new standards that open up greater opportunities.