Logo of Huzzle

Home

Matches

Explore

Manage

Gene Therapy/Biologics (AAV) Upstream Process Development Intern

image

Sarepta Therapeutics

Jan 11, 2024

Applications are closed

  • Internship
    Full-time
    Starts on May 27
    Summer Internship
  • Science
  • Columbus

Requirements

  • Enrolled in an undergraduate or graduate program with a major in Chemical/Biomedical/Biochemical Engineering, Biochemistry, Biology, Bioengineering, or a related discipline of study
  • Enrolled in a 4-year accredited university/college, including enrollment in the Fall Semester after completing the internship. At a minimum, summer interns should have completed their freshman year in college/graduate school
  • Previous experience with mammalian or microbial cell culture preferred
  • In good academic standing within their program and the university
  • Highly motivated and passionate about the biopharmaceutical industry and learning about industry technology
  • High degree of initiative and attention to detail
  • Able to work under supervision and independently
  • Good written and verbal communication skills as well as strong interpersonal skills
  • Proven record of teamwork, adaptability, problem-solving skills, innovation, and integrity

Responsibilities

  • Day-to-day research focusing on solving key challenges in biopharmaceutical Upstream process development, process characterization, and manufacturing of AAVs
  • Assisting in the operation of cell culture bioreactor systems including Ambr15 and Ambr250
  • Collaborating with teams of scientists in the areas of cell line development and screening, upstream process development, cell line engineering, high throughput screening, media development, -omics, continuous processing, downstream process development, and Vector Core
  • Participating in departmental and project team meetings to provide a broad perspective on the drug development process in the pharmaceutical industry
  • Recording of experimental details and for analysis and interpretation of data that may be used for internal or external scientific publications and/or patents which may follow from the internship
  • Gaining further knowledge and skill sets via refinement of laboratory skills, introduction to new experimental techniques, exposure to current challenges in bioprocess research, and perspectives on the practical aspects of drug development
  • Understanding biochemistry, statistical data analysis, and general engineering principles
  • Learning and performing mammalian cell culture aseptic techniques at various bench scales and bioreactor platforms
  • Supporting the design, execution, and analysis of lab experiments with the objective of cell culture process development using state-of-the-art lab-scale and high throughput bioreactors
  • Facilitating the routine operation of the high throughput bioreactor systems
  • Assisting in conducting experiments to optimize process parameters in the aim of maximizing AAV vector productivity and quality
  • Documenting and interpreting data to support cell culture process development and characterization
  • Training on all major equipment and processes in the cell culture lab
image

Sarepta Therapeutics

Dragging Tomorrow Into Today.

Science & Healthcare
Industry
1001-5000
Employees
1980
Founded Year

Mission & Purpose

Sarepta Therapeutics, headquartered in Cambridge, Massachusetts, is a global biotechnology company on an urgent mission: engineer precision genetic medicine for rare diseases that devastate lives and cut futures short. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development. Our vast pipeline is driven by our multi-platform Precision Genetic Medicine Engine in gene therapy, RNA and gene editing.