Grad Intern – R&D (De novo Protein Design)

Amgen

Oct 18, 2023

Applications are closed

Internship
Full-time
Off-cycle Internship
Research & Development
Science
United States
Remote

Requirements

Basic Qualifications:
Amgen requires that all individuals applying for a grad internship or a co-op assignment at Amgen must meet the following criteria:
18 years or older
Graduated with a Bachelor’s degree from an accredited college or university with a 3.0 minimum GPA or equivalent
Currently enrolled in an MBA program for an MBA internship OR a Master’s program for a Master’s internship OR a PharmD program for a PharmD internship OR Ph.D. for a PhD internship from an accredited college or university and completion of the first year of MBA OR Master’s OR Pharm D OR Ph.D. program before the internship starts
Enrolled in an accredited college or university following the potential internship or co-op assignment
Must not be employed at the time the internship starts
Student must be located in the United States for the duration of the internship OR co-op
Preferred Qualifications:
Degree concentration(s) in Biochemistry, Structural Biology, Computer Science, Bioengineering, Bioinformatics, or related area
Familiarity with Unix-based high performance computation environments
Familiarity with Python or other programming languages
Familiarity with protein structure and protein structure visualization (i.e. PyMOL) and design tools (i.e. Rosetta, proteinMPNN, MOE, Schrodinger)
Familiarity with ML-based protein structure prediction and design tools (i.e. AlphaFold, OmegaFold, RFDiffusion, etc.) is a plus

Responsibilities

This internship explores the use of tools of protein design to develop molecules to improve the high-throughput structure determination of potential therapeutic proteins. The successful intern will collaborate with structural biologists and other protein designers to generate novel protein sequences, which will then be produced and tested in the lab. They will use the most current AI-based and conventional tools of protein design to generate pools of candidate tool proteins, to address an unmet technical need in therapeutic protein structural biology. Well-suited applicants will have experience in computational protein design and familiar with the methods of biochemistry and structural biology.
The intern will gain experience in protein evaluation and design in an industrial setting and will have the opportunity to interact with various computational and experimental functions within Amgen. This opportunity will allow the intern to see first-hand how early-stage large molecule drug development is conducted.

Amgen

#WeareBiotech

Science & Healthcare

Industry

10,001+

Employees

1980

Founded Year

Mission & Purpose

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world's leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.