The candidate must have a background in Drug Metabolism, Pharmacokinetics, Chemistry, or a related field, along with proficiency in wet lab techniques and experimental design. They should have a strong desire to learn new techniques and a commitment to continuous learning and skill development. Excellent critical thinking and scientific skills, as well as strong oral and written communication skills, are also required.

The candidate will be responsible for characterizing catabolism pathways of oligonucleotides, developing high-throughput assays, conducting DMPK studies, adapting ADME assays, and delivering presentations.

Science

United States

San Francisco

Medium

Denali Therapeutics is dedicated to defeating neurodegenerative diseases by breaking through historical barriers in scientific research and clinical development in order to deliver safe and effective medicines to patients and families.  Our scientific approach is based on three core principles: rigorous assessment of genetic targets, engineering brain delivery, and using biomarkers to guide development.

Our team thrives in a work environment that is scientifically driven, impact-focused, supportive, and collaborative. Our ability to have a positive impact on people’s lives is directly related to the trust we have in each other and our ability to unify our diverse backgrounds and experience behind our purpose to defeat degeneration.

Science & Healthcare

Denali Therapeutics

<ul><li>Denali is seeking to hire a motivated intern in the DMPK group who is interested in mass spectrometry (MS) and absorption, distribution, metabolism and excretion (ADME) sciences applied in drug discovery and early development. Under the guidance of DMPK group, the candidate for this position will contribute to assay development for characterizing the distribution, catabolism, and excretion of oligonucleotides. This role requires a strong technical background in mass spectrometry, ideally with experience generating and interpreting high resolution mass spectral data for complex molecules. This position entails hands-on experience in wet laboratory techniques and experimental design, involving the coordination of cross-functional activities, meticulous documentation of results, and effective communication of findings. The role offers a unique opportunity for collaboration with scientists from various disciplines including Discovery Chemistry, Safety Assessment, Biology, and Development Sciences.</li></ul>

Bachelors

Masters

Denali is seeking to hire a motivated intern in the DMPK group who is interested in mass spectrometry (MS) and absorption, distribution, metabolism and excretion (ADME) sciences applied in drug discovery and early development. Under the guidance of DMPK group, the candidate for this position will contribute to assay development for characterizing the distribution, catabolism, and excretion of oligonucleotides. This role requires a strong technical background in mass spectrometry, ideally with experience generating and interpreting high resolution mass spectral data for complex molecules. This position entails hands-on experience in wet laboratory techniques and experimental design, involving the coordination of cross-functional activities, meticulous documentation of results, and effective communication of findings. The role offers a unique opportunity for collaboration with scientists from various disciplines including Discovery Chemistry, Safety Assessment, Biology, and Development Sciences.

Intern, DMPK – Oligonucleotide Discovery/Development

Requirements

Responsibilities

Denali Therapeutics

Mission & Purpose