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Summer 2025 - Quantitative systems Pharmacology & Physiologically Based Pharmacokinetics Internship

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Bristol Myers Squibb

Sep 20, 2024

  • Internship
    Full-time
    Virtual Internship
  • Princeton
    Remote
  • Quick Apply

AI generated summary

  • You should be a student in math, engineering, or pharmaceutical disciplines with strong math skills, knowledge of ODEs, parameter estimation, and familiarity with MATLAB/SimBiology.
  • You will develop mechanistic models, calibrate them with data, identify sensitive parameters, integrate pathway knowledge, analyze clinical data, and participate in virtual intern activities.

Requirements

  • Student in mathematics, engineering (chemical, biomedical, others), physics, or pharmaceutical disciplines including drug metabolism and pharmacokinetics with strong mathematical background
  • Solid knowledge of modeling using ordinary differential equations and numerical solvers
  • Knowledge of how to perform parameter estimation and sensitivity analysis
  • Experience with MATLAB/SimBiology environment is beneficial

Responsibilities

  • Develop and parametrize mechanistic models using systems of ordinary differential equations
  • Calibrate parametrized mini-models using in-house data or data available in the public domain
  • Identify and determine physiological range of the most sensitive parameters
  • Incorporate pathway knowledge into platforms and test functionality with respect to existing therapies
  • Assist in the analysis of discovery, toxicology, and clinical data
  • Participate in the BMS Virtual Intern Program activities

FAQs

What is the focus of the internship?

The internship focuses on mechanistic modeling projects and the development and improvement of models related to pharmacokinetics and pharmacodynamics under the guidance of experienced scientists.

What academic background is required for this internship?

Candidates should be students in mathematics, engineering (chemical, biomedical, etc.), physics, or pharmaceutical disciplines, with a strong mathematical background.

Are there specific technical skills required for the internship?

Yes, candidates should have solid knowledge of modeling using ordinary differential equations and numerical solvers, as well as experience with parameter estimation and sensitivity analysis. Experience with MATLAB/SimBiology is beneficial.

What types of projects will the intern work on?

Potential projects include the assessment and development of methods for small molecule absorption, distribution, metabolism, excretion, and drug-drug interactions, as well as developing mini-models for pathways relevant to drug discovery, toxicology, and clinical efforts.

Will there be networking opportunities during the internship?

Yes, the successful candidate will have cross-functional networking opportunities as part of the Bristol Myers Squibb Virtual Intern Program.

Is on-site presence required for this role?

The internship may involve a hybrid work model, with an emphasis on collaboration, innovation, and positive company culture.

Is this internship suitable for graduate students?

Yes, both college and graduate students are encouraged to apply for the internship.

What kind of support does Bristol Myers Squibb offer for employees?

Bristol Myers Squibb offers a wide variety of competitive benefits, services, and programs to help employees pursue their personal and professional goals.

What is the duration of the internship?

This is a summer internship for Summer 2025.

How does Bristol Myers Squibb ensure diversity and inclusion in the workplace?

The company promotes diversity through its values of passion, innovation, urgency, accountability, inclusion, and integrity, allowing individual talents and unique perspectives to thrive.

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Bristol Myers Squibb

Manufacturing & Electronics
Industry
10,001+
Employees

Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.