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Summer 2025 - X-Ray Crystallography Internship

  • Internship
    Full-time
    Summer Internship
  • Science
    Research & Development
    Sustainability
  • Princeton
  • Quick Apply

AI generated summary

  • You should have two years of undergraduate study, strong analytical and communication skills, and a basic understanding of protein biochemistry. Preferred majors include Chemistry and Biophysics.
  • You will express and purify proteins, characterize them, prepare samples for cryo-EM, operate the microscope, screen samples, and analyze data for 3D structure determination.

Requirements

  • Completed at least two years of undergraduate coursework at a university
  • Strong analytical and organizational skills
  • Excellent communication, collaboration and learning skills
  • Preferred majors: Chemistry, Biochemistry, Biophysics, Biology
  • Basic understanding of protein biochemistry
  • Basic lab technique skills

Responsibilities

  • Protein expression in bacterial and/or mammalian cells
  • Protein purification using affinity, size exclusion, ion exchange chromatography
  • Protein characterization using biophysical methods
  • Preparation of samples for cryo-electron microscope
  • Cryo-electron microscope operation, sample screening, analysis and data collection
  • 3-dimensional structure determination theory

FAQs

What is the focus of the internship?

The focus of the internship is on Cryo-Electron Microscopy (Cryo-EM), specifically purifying proteins for this method and optimizing the sample preparation workflow.

What major should I be studying to qualify for this internship?

Preferred majors include Chemistry, Biochemistry, Biophysics, and Biology.

What skills are required for this internship?

Required skills include strong analytical and organizational abilities, excellent communication, collaboration and learning skills, and a basic understanding of protein biochemistry.

What kind of laboratory techniques will I be expected to use during the internship?

You will be expected to use affinity chromatography, size exclusion chromatography, ion exchange chromatography, and basic biophysical characterization methods.

Is prior experience in X-ray crystallography or Cryo-EM necessary?

No, prior experience in X-ray crystallography or Cryo-EM is not mentioned as necessary, but a basic understanding of protein biochemistry is recommended.

How will the internship contribute to my career development?

The internship offers unique opportunities to grow and thrive through meaningful work, learning from high-achieving teams in a diverse environment, while contributing to transformative research that impacts patients' lives.

Will there be hands-on training involved with the Cryo-Electron Microscope?

Yes, the internship includes training on Cryo-Electron microscope operation, sample screening, analysis, and data collection.

Is this internship open to students who have not yet completed their degree?

Yes, applicants must have completed at least two years of undergraduate coursework, but they do not need to have completed their degree.

What is the work environment like at Bristol Myers Squibb?

Bristol Myers Squibb offers a balance and flexibility in the work environment, with a diverse culture that promotes inclusion and collaboration.

Are accommodations available for applicants with disabilities?

Yes, BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process and provides reasonable workplace accommodations upon request.

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Mission & Purpose

At Bristol Myers Squibb, we work every day to transform patients’ lives through science. That work inspires some of the most interesting, meaningful, and life-changing careers you’ll experience. Join us and pursue innovative ideas alongside some of the brightest minds in biopharma, collaborating with a team rich in diversity of experiences, and perspectives. We have built a sustainable pipeline of potential therapies and are leveraging translational medicine and data analytics to understand how we can deliver the right medicine to the right patient, at the right time, to achieve the best outcome. Whether in a scientific, business or supporting function, a career at BMS means you’ll be inspired every day to grow and thrive through opportunities that are uncommon in scale and scope. Here, you’ll be on the cutting edge of powerful innovation in oncology, hematology, immunology, cardiovascular disease, and fibrosis, with colleagues united in the mission to help patients. Through the Bristol Myers Squibb Foundation, we also promote health equity and seek to improve health outcomes of populations disproportionately affected by serious diseases and conditions. Our mission is to give new hope to help patients prevail over serious disease – it drives everything we do.