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Research Associate - Molecular Biologist

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King's College London

Sep 8, 2024

Applications are closed

  • Job
    Full-time
    Entry, Junior & Mid Level
  • Research & Development
  • London

Requirements

  • Essential Criteria
  • PhD awarded in relevant discipline related to Molecular & Cellular Biology or Immunology (or pending results)
  • A keen interest and background in translational cancer research.
  • Knowledge of cancer biology, particularly the tumour microenvironment
  • Experience in tumour 3D culture/co-culture systems (tumour cell spheroid and/or organoid culture) and their treatment with chemotherapeutics and targeted agents.
  • Expertise in nucleic acid isolation, RT-PCR and quantitative PCR.
  • Experience in light microscopy techniques e.g. confocal imaging, light-sheet imaging.
  • Previous publications, abstracts and presentations at national or international meetings
  • Experience in SDS-PAGE/western blotting and related techniques such as cell lysate preparation and determination of protein concentration.
  • Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.
  • Desirable criteria
  • Experience with and knowledge of advanced molecular biology techniques such as quantitative PCR, Nanopore sequencing, and TapeStation analysis
  • Experience in isolation and analysis of extracellular vesicles, in particular cancer exosomes.
  • Experience with CRISPR/Cas9 technology, including the CRISPR activation (CRISPRa) technique.

Responsibilities

  • - Developing and maintaining PDOs
  • - Applying a number of molecular and cell biology and imaging assays in order to identify and model the tumour genomic and immune changes that will distinguish patients that will have high and low risk of recurrence after primary treatment

FAQs

What is the job title for this position?

The job title is Research Associate - Molecular Biologist.

Where is the position located?

The position is located at the Comprehensive Cancer Centre (CCC) at King’s College London (KCL).

What kind of research will the postholder be involved in?

The postholder will be involved in collaborative research projects focusing on the use of patient-derived organoids (PDOs) and imaging techniques to study tumour-immune cell interactions and distinguish between high and low-risk cancer patients.

What are the essential qualifications for this role?

The essential qualifications include a PhD in a relevant discipline related to Molecular & Cellular Biology or Immunology, an interest in translational cancer research, knowledge of cancer biology, experience in tumour 3D culture systems, expertise in nucleic acid isolation, and previous publications or presentations.

Is there an opportunity for candidates pending their PhD results?

Yes, candidates who have submitted their thesis and are awaiting the award of their PhD will be considered for the position, and they will be appointed at Grade 5 with the title of Research Assistant until their PhD is awarded.

What are some desirable qualifications for this position?

Desirable qualifications include experience with advanced molecular biology techniques such as quantitative PCR, knowledge of extracellular vesicles, and experience with CRISPR/Cas9 technology.

What is the duration of the contract?

The contract is fixed-term until 30/06/2026.

How should candidates apply for this position?

Candidates should submit a copy of their CV and a supporting statement detailing how they meet the essential criteria listed in the job advert.

Are there any additional requirements for the role?

Yes, the post is subject to Occupational Health clearances.

Does this role support diversity and inclusion?

Yes, the institution is committed to supporting diversity and inclusion, embracing a culture where everyone is welcomed and feels connected.

Are candidates requiring sponsorship eligible to apply?

No, this role does not meet the requirements for sponsorship for candidates who require the right to work in the UK.

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King's College London

Education
Industry
5001-10,000
Employees

Mission & Purpose

King’s College London is amongst the top 40 universities in the world and top 10 in Europe (THE World University Rankings 2024), and one of England’s oldest and most prestigious universities.  With an outstanding reputation for world-class teaching and cutting-edge research, King’s maintained its sixth position for ‘research power’ in the UK (2021 Research Excellence Framework).   King's has more than 33,000 students (including more than 12,800 postgraduates) from some 150 countries worldwide, and 8,500 staff. For nearly 200 years, King’s students and staff have used their knowledge and insight to make a positive impact on people, society and the planet. Focused on delivering positive change at home in London, across the UK and around the world, King’s is building on its history of addressing the world’s most urgent challenges head on to accelerate progress, make discoveries and pioneer innovation. Visit the website to find out more about Vision 2029, which sets out bold ambitions for the future of King’s as we look towards our 200th anniversary.