Senior Scientist - PAT/Spectroscopy

Thermo Fisher Scientific

Jun 30, 2024

Applications are closed

Job
Full-time
Mid & Senior Level
Science
Boston

Requirements

Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar
Sr. Scientist: Previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 4+ years’)
OR Masters degree and previous experience that provides the knowledge, skills, and abilities to perform the job (comparable to 2+ years’)
OR PhD
In some cases, an equivalency, consisting of a combination of appropriate education, training and/or directly related experience, will be considered sufficient for an individual to meet the requirements of the role.
Knowledge, Skills and Abilities:
Hands-on experience with evaluating and/or implementing PAT tools for real-time monitoring of bioreactor
Experience using ML such as PCA, PLS, and clustering methods
Experience developing and deploying chemometric models for quantitative analysis of bioreactor status
Proficiency with scripting languages such as Matlab, Python or R and analytical softwares such as JMP, SIMCA, Unscrambler, etc.
Familiarity with data visualization tools such as PowerBI, Spotfire
Understanding of bioprocessing, gene therapy process development, characterization, and manufacturing
Team player, innovative, collaborative, and initiative
Working Environment:
Below is listed the working environment/requirements for this role:
Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
Able to work upright and stationary and/or standing for typical working hours.
Able to lift and move objects up to 25 pounds
Able to work in non-traditional work environments.
Able to use and learn standard office equipment and technology with
proficiency.
May have exposure to potentially hazardous elements, including infectious agents, typically found in healthcare or laboratory environments.
Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.

Responsibilities

Evaluate and develop analytical methods for real-time monitoring of cell therapies using enabling technologies and traditional process analytical technologies
Evaluate and develop on-line, in-line, or at-line analytical methods for process monitoring, in-process analytics, and process characterization
Development of spectroscopic methods (Raman, NIR, FTIR) for process monitoring of biologics such as mAbs, proteins, viral vaccines, or gene therapy vectors. Preferred experience with cell therapy products
Experience with in-line probes, such as capacitance and Raman spectroscope, and development of statistical and regression models using advanced data analytics
Experience developing at-line or online methods using process automation, miniaturization, or high-throughput analytics
Experience in professional capacity developing soft sensors and statistical process models using data science approaches such as ML and AI
Familiarity or experience with robotic liquid handlers such as TECAN or Hamilton and their associated scripting software

FAQs

What education and experience are required for the Senior Scientist - PAT/Spectroscopy position?

The minimum requirement is a Bachelor's degree in lab sciences such as Chemistry, Biochemistry, Material Science, Immunology, Biology, Molecular Biology or similar. Previous experience is also required, with equivalent experience of 4+ years for a Sr. Scientist position or 2+ years with a Master's degree.

What are the key responsibilities of a Senior Scientist - PAT/Spectroscopy?

Key responsibilities include evaluating and developing analytical methods for real-time monitoring of cell therapies using enabling technologies, developing spectroscopic methods for process monitoring of biologics, developing statistical and regression models using advanced data analytics, and familiarity with robotic liquid handlers.

What skills are required for this role?

Skills required include hands-on experience with evaluating PAT tools for real-time monitoring, proficiency with scripting languages and analytical softwares, experience with data visualization tools, understanding of bioprocessing and gene therapy process development, and being a team player, innovative, collaborative, and initiative.

What is the working environment like for a Senior Scientist - PAT/Spectroscopy?

The working environment may include communicating with diverse groups of people, working upright and stationary for typical hours, lifting objects up to 25 pounds, working in non-traditional environments, using standard office equipment and technology, and potential exposure to hazardous elements typically found in healthcare or laboratory environments. Successful performance under pressure while handling multiple projects is also required.

Thermo Fisher Scientific

The World Leader In Serving Science

Science & Healthcare

Industry

10,001+

Employees

Mission & Purpose

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.